Investigators say the fire started around 3 a.m. on the fifth floor of a building inside the Pomonok Houses complex at 71st Avenue and 156st Street in Kew Gardens Hills.
The victim has been identified as Bianca Kuros, 44.
Officials say it took more than a hundred firefighters and an hour to contain the flames.
Three other people were taken to the hospital with serious injuries and four firefighters suffered minor injuries.
The Red Cross is also helping a displaced family find housing.
The cause of the fire remains under investigation.