The incident occurred just after 5 a.m. on Thursday along the Prospect Expressway in Windsor Terrace.
Firefighters and police responded to a traffic collision that caused one vehicle to burst into flames. Police closed all eastbound lanes of the Prospect Expressway from Fort Hamilton Parkway.
EMS treated four people who were injured from the collision.
Two of the victims suffered serious but non life-threatening injuries and the other two suffered minor injuries.
No word on what caused the accident.